EFFECTS OF A CALCIUM BINDER ON THE SOLUBILITY OF BILE-ACIDS AND FATTY-ACIDS IN THE LARGE-INTESTINE OF THE RAT

Kidney stone patients with hypercalciuria type I are treated with an o ral calcium binder. Lower intakes of calcium (Ca) in the range of 0-15 00 mg/day have been associated with an increased incidence of colorect al cancer. The aim of this study is to analyze the effects of feeding ethylene diamine tetraacetic acid sodium salt (EDTA), a strong, nonabs orbable binder of Ca, on the solubility of bile acids (BA) and long ch ain fatty acids (LCFA) in the large intestine of the rat. We have show n that the concentrations of soluble BA and LCFA in the large intestin e contents remained constant while the concentration of total BA and L CFA decreased. Therefore, lowering the amount of Ca available for bind ing BA or LCFA is unlikely to increase the risk of colorectal cancer b y that method.