BIOCOMPATIBILITY OF XENOGENEIC BONE, COMMERCIALLY AVAILABLE CORAL, A BIOCERAMIC AND TISSUE SEALANT FOR HUMAN OSTEOBLASTS

The drawbacks of freshly harvested autologous bone have resulted in th e search for an alternative, capable of supporting osteogenic cell gro wth. This capability was examined in potential bone graft materials by culturing human osteoblasts on each material. Test materials included rat bone, Surgibone(R), Ostilit(R), Biocoral(R) and Tisseel(R). After 3 days osteoblasts had adhered to all materials, except Ostilit(R). W ith increasing time the cells multiplied on the materials, to varying extents. Cell affinity was greatest for rat bone and Tisseel(R). Fewer cells attached to Biocoral(R) and Surgibone(R). Thus all the material s, with the exception of Ostilit(R), were biocompatible for human oste oblasts.