THE EFFECT OF PHARMACOLOGICAL STIMULATION AND BLOCKADE OF AUTONOMIC RECEPTORS AND OF PUDENDAL BLOCKADE ON URETHRAL STRESS-RELAXATION IN HEALTHY WOMEN

Citation
P. Thind et al., THE EFFECT OF PHARMACOLOGICAL STIMULATION AND BLOCKADE OF AUTONOMIC RECEPTORS AND OF PUDENDAL BLOCKADE ON URETHRAL STRESS-RELAXATION IN HEALTHY WOMEN, British Journal of Urology, 74(1), 1994, pp. 86-92
Citations number
28
Categorie Soggetti
Urology & Nephrology
Journal title
ISSN journal
00071331
Volume
74
Issue
1
Year of publication
1994
Pages
86 - 92
Database
ISI
SICI code
0007-1331(1994)74:1<86:TEOPSA>2.0.ZU;2-D
Abstract
Objective To examine the influence of autonomic receptor stimulation a nd blockade (noradrenaline, prazosin, terbutaline, propranolol, carbac hol and atropine), and of pudendal nerve blockade on urethral stress r elaxation. Subjects and methods Forty healthy women were evaluated. Th e stress relaxation parameter was defined as the relative rate of pres sure decrease during a fixed period of time following a rapid dilatati on of the urethra. The dilatation was performed by water-infusion into a small rubber cylinder placed in the urethra. Results The drugs did not affect stress relaxation significantly, whereas the pudendal block ade produced a significant change along the length of the urethra char acterized by a faster pressure decay following dilatation. Conclusion In women, stress relaxation in the urethra relies significantly on the pudendal nerve-innervated striated muscles.