NEW GLYCOLIPIDS (CHITOOLIGOSACCHARIDE DERIVATIVES) POSSESSING IMMUNOSTIMULATING AND ANTITUMOR ACTIVITIES

Citation
Vi. Gorbach et al., NEW GLYCOLIPIDS (CHITOOLIGOSACCHARIDE DERIVATIVES) POSSESSING IMMUNOSTIMULATING AND ANTITUMOR ACTIVITIES, Carbohydrate research, 260(1), 1994, pp. 73-82
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
ISSN journal
00086215
Volume
260
Issue
1
Year of publication
1994
Pages
73 - 82
Database
ISI
SICI code
0008-6215(1994)260:1<73:NG(DPI>2.0.ZU;2-T
Abstract
New glycolipids, derived from chitooligosaccharides of dp 2-4 and cont aining both free and acylated amino groups, were synthesized. The stru cture of the key compounds (di-, tri-, and tetra-saccharides acylated with different fatty acids) were elucidated by C-13 NMR spectroscopy. Only the amino group of the reducing end of the chitooligosaccharides was found to be acylated when equimolecular amounts of reagents were u sed. The compounds obtained were shown to possess a low toxicity and c ertain immunostimulatory and antitumor activities. An induction of int erleukin-1 and tumor necrosis factor by the immunocompetent cells and an augmentation by 140-180% of the mean life of mice with the Erlich c arcinoma were observed.