HEPATIC BILIARY TRANSPORT AFTER HEPATOCYTE TRANSPLANTATION IN EIZAI HYPERBILIRUBINEMIC RATS

Authors
HAMAGUCHI H YAMAGUCHI Y GOTO M MISUMI M HISAMA N MIYANARI N MORI K OGAWA M
Citation
H. Hamaguchi et al., HEPATIC BILIARY TRANSPORT AFTER HEPATOCYTE TRANSPLANTATION IN EIZAI HYPERBILIRUBINEMIC RATS, Hepatology, 20(1), 1994, pp. 220-224
Citations number
24
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
Hepatology → ACNP
ISSN journal
02709139
Volume
20
Issue
1
Year of publication
1994
Part
1
Pages
220 - 224
Database
ISI
SICI code
0270-9139(1994)20:1<220:HBTAHT>2.0.ZU;2-P
Abstract
The Eizai hyperbilirubinemic rat (EHBR) is a Sprague-Dawley mutant rat with conjugated hyperbilirubinemia. Eizai hyperbilirubinemic rats hav e impaired canalicular excretory transport of organic anions, bile aci d glucuronide and sulfate. Eizai hyperbilirubinemic rats, with and wit hout a 68% partial hepatectomy, were treated by an intraportal injecti on of 1 x 10(7) wild-type Sprague-Dawley mutant rat hepatocytes. Serum bilirubin concentrations decreased significantly after hepatectomy an d intraportal injection. Biliary excretion was demonstrated by biliary transport of indocyanine and sulfobromophthalein into the bile. These results indicate that hepatic transport of bile acid conjugates in Ei zai hyperbilirubinemic rats can be restored by hepatocyte transplantat ion in conjunction with the recipient's excretory biliary system.