OBSTETRICAL AND GYNECOLOGICAL COMPLICATIONS IN FRAGILE-X CARRIERS - AMULTICENTER STUDY

We have conducted a multicenter obstetrical and gynecological survey o f women in fragile X families. Included in the study were 131 gene car riers (39 with a full mutation and 92 with a premutation) and 109 nonc arriers. Analysis indicated that higher numbers of fragile X gene carr iers reported having irregular menses and other gynecological complica tions. As a group they also experienced cessation of menses prior to a ge 40 years at a significantly higher rate. The data appear to indicat e that the FMR1 gene may play a role in the development and proliferat ion of oogonia. (C) 1994 Wiley-Liss, Inc.