A. Felinger et G. Guiochon, OPTIMIZING EXPERIMENTAL CONDITIONS FOR MINIMUM PRODUCTION COST IN PREPARATIVE CHROMATOGRAPHY, AIChE journal, 40(4), 1994, pp. 594-605
Optimum experimental conditions and column design parameters are calcu
lated for most economical separation of binary mixtures by preparative
liquid chromatography. The solvent consumption and capital costs are
regarded as the two major cost contributions. Calculations were perfor
med by using the numerical solution of the equilibrium-dispersive mode
l of chromatography and a nonlinear simplex algorithm. Solvent consump
tion depends only on the column efficiency, the retention factor, and
the loa&ng factor. The production rate depends on the particle size, t
he column length, the mobile-phase flow velocity, the retention and th
e loading factors, and can be optimized with or without recovery yield
constraints. A hybrid objective function was constructed to find the
tradeoffs between the production rate and the solvent consumption.