HISTOLOGY IN MASTOPATHY AND CUMULATIVE IP SILATERAL PATHOGENESIS OF BREAST-CARCINOMA

In a retrolective and follow-up study the ipsilateral cumulative risk of breast carcinoma after histological benign diseases in women under 66 years of age (n = 1397) is investigated. The subtypes are mastopath y I (= changes without proliferative lesions), mastopathy II (= prolif erative lesions without atypia), and mastopathy III (id sunt atypical ductal and lobular hyperplasias). The cumulative risk with mastopathy I and II over a 15 year time period corresponds with the ordinary age related risk, the cumulative risk with mastopathy III is four times hi gher (p = 0.001). There is no difference between atypical ductal and l obular hyperplasia (p = 0.7). Women in reproductive age have a higher risk (p = 0.03), which exists even after a carcinoma-free survival of more than 10 years. The mastopathy is more a stigma for a higher breas t cancer risk than a direct precancerous lesion.