In spontaneous breathing intrathoracic pressure alternates between pos
itive and negative in a biphasic sequential pattern. By contrast, duri
ng mechanical ventilation (IPPV, CPPV) the intrathoracic pressure rema
ins above atmospheric all the time. Due to these unphysiological condi
tions there are extensive causal and side effects on the lung parenchy
ma and other organs. Erros in the artificial ventilation technique can
magnify these effects. In order to minimize these deleterious effects
of positive pressure ventilation it is essential to keep the procedur
e as short and little invasive as possible. The following strategy ena
bles this goal to be brought closer: 1) early commencement of ventilat
ion; 2) optimal adjustment of artificial ventilation to the individual
needs of the patient, 3) early weaning from assisted ventilation thro
ugh augmented rather than controlled modes of ventilation: 4) kinetic
therapy (systematic changing of the patient's position) with the back
up of the requisite thoracic CT scan findings; 5) reduction of the inv
asiveness of the procedure in order to ensure early commencement of sp
ontaneous respiration.