ANTINEOPLASTIC AND CYTOGENETIC EFFECTS OF COMPLEXES OF PD(II) WITH 4N-SUBSTITUTED DERIVATIVES OF 2-ACETYL-PYRIDINE-THIOSEMICARBAZONE

Authors
PAPAGEORGIOU A IAKOVIDOU Z MOURELATOS D MIOGLOU E BOUTIS L KOTSIS A KOVALADEMERTZI D DOMOPOULOU A WEST DX DERMETZIS MA
Citation
A. Papageorgiou et al., ANTINEOPLASTIC AND CYTOGENETIC EFFECTS OF COMPLEXES OF PD(II) WITH 4N-SUBSTITUTED DERIVATIVES OF 2-ACETYL-PYRIDINE-THIOSEMICARBAZONE, Anticancer research, 17(1A), 1997, pp. 247-251
Citations number
14
Categorie Soggetti
Oncology
Journal title
Anticancer research → ACNP
ISSN journal
02507005
Volume
17
Issue
1A
Year of publication
1997
Pages
247 - 251
Database
ISI
SICI code
0250-7005(1997)17:1A<247:AACEOC>2.0.ZU;2-T
Abstract
The effect of novel Pd(II) complexes with derivatives of 2-acetyl-pyri dinethisemicarbazone, N4-ethyl (HAc4Et) and 3-hexamethyleneiminylthios emicarbazone (HAchexim), on Sister Chromatid Exchange (SCE) rates and human lymphocyte proliferation kinetics was studied. Also, the effect of Pd(II) complexes on DNA synthesis of P388 and L1210 cell cultures a nd against Leukemia P388 was investigated. Among these compounds, the compound thyleneiminyl-2-acetylpyridine-thisemicarbazonato) palladium (II) was found to be distinctly effective against Leukemia P388, in in hibiting incorporation of H-3-thymidine into DNA and in inducing SCEs and cell division delays.