MIB1 (KI-67) EXPRESSION IN NON-HODGKINS-LYMPHOMAS

The MIBI monoclonal antibody which is used as a marker of cell prolife ration was studied by immunohistochemistry on formalin-fixed and paraf fin embedded biopsy specimens of lymph nodes in 40 high- and 46 lowgra de cases of non-Hodgkin's lymphomas (NHL) classified according to rite Kiel classification. All cases were found to display nuclear MIBI sta ining. A statistically significant difference (P < 0,005) was found be tween high- and low grade NHLs and this indicates that the high- grade NHL display a higher proliferation rate than low grade. In addition, remarkable variations in MIBI expression were found among individual c ases of the same histological group. These data may suggest that MIBI index can help in the individual approach of file proliferation rate o f each tumour and this may be an important parameter in association wi th clinical and other laboratory parameters for predicting the biologi cal behaviour of non-Hodgkin's lymphomas.