Auditory verbal learning and memory was assessed in 18 patients with m
oderate-severe closed-head injury (CHI). Compared to a matched control
group, performance of the CHI subjects on all measures of the Auditor
y Verbal Learning Test (AVLT) was significantly worse. Discriminant fu
nction analysis correctly classified 90% of subjects as CHI or control
using the three most reliable measures of the AVLT. Retention of the
learning list following the distractor trial varied with severity of i
njury as indexed by duration of post-traumatic amnesia (PTA). The more
severe the injury (longer PTA), the fewer words were recalled after i
nterference (r = -0.72). Susceptibility of verbal memory to retroactiv
e interference is sensitive to the presence and severity of CHI.