ELECTROCHEMICAL STUDY OF IPRONIAZID AND ITS ANALYTICAL DETERMINATION BY DIFFERENTIAL-PULSE POLAROGRAPHY

Iproniazid was found to be irreversibly reduced in two steps, involvin g the exchange of two electrons and two protons each, by using tast po larography, normal pulse polarography, (NPP), and cyclic voltammetry ( CV). The rate constants of these two steps were found to be 5.8 x 10(- 6) and 4.2 X 10(-6) and 4.2 x 10(-6) cm s-1, respectively, and their c orresponding diffusion coefficients 4.5 x 10(-6) and 8.3 x 10(-5) cm2 s-1. Also, alpha, the coefficient of cathodic transfer, was found to b e 0.20 to 0.25 for the first peak and 0.17 to 0.15 for the second. On the basis of the electrochemical study performed, a differential pulse polarographic method for the determination of iproniazid over the con centration range of 5 x 10(-7) M to 1 X 10(-4) M was developed.