DOPAMINE INDUCES APOPTOSIS IN CULTURED RAT STRIATAL NEURONS - POSSIBLE MECHANISM OF D-2-DOPAMINE RECEPTOR NEURON LOSS DURING AGING

Authors
SHINKAI T ZHANG L MATHIAS SA ROTH GS
Citation
T. Shinkai et al., DOPAMINE INDUCES APOPTOSIS IN CULTURED RAT STRIATAL NEURONS - POSSIBLE MECHANISM OF D-2-DOPAMINE RECEPTOR NEURON LOSS DURING AGING, Journal of neuroscience research, 47(4), 1997, pp. 393-399
Citations number
21
Categorie Soggetti
Neurosciences
Journal title
Journal of neuroscience research → ACNP
ISSN journal
03604012
Volume
47
Issue
4
Year of publication
1997
Pages
393 - 399
Database
ISI
SICI code
0360-4012(1997)47:4<393:DIAICR>2.0.ZU;2-S
Abstract
We examined D-2-dopamine receptor containing neurons in cultures of ne onatal rat striatum for apoptosis following dopamine treatment. Exposu re to cultures to micromolar concentrations of dopamine resulted in 60 -70% killing of D-2-dopamine receptor neurons within 24 hr. We also ut ilized a double labeling procedure to determine that treatment with do pamine induced apoptosis in D-2-dopamine receptor containing neurons. These results suggest that loss of D-2-dopamine receptor containing ne urons during aging could be due to an apoptotic effect of dopamine. (C ) 1997 Wiley-Liss, Inc.(dagger)