NUCLEOSIDES AND NUCLEOTIDES .130. THE SYNTHESIS OF IMIDAZO[4,5-E][1,4]DIAZEPINE NUCLEOSIDES FROM N-1-SUBSTITUTED INOSINES

Authors
AOYAGI M MINAKAWA N MATSUDA A
Citation
M. Aoyagi et al., NUCLEOSIDES AND NUCLEOTIDES .130. THE SYNTHESIS OF IMIDAZO[4,5-E][1,4]DIAZEPINE NUCLEOSIDES FROM N-1-SUBSTITUTED INOSINES, Nucleosides & nucleotides, 13(6-7), 1994, pp. 1535-1549
Citations number
21
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
13
Issue
6-7
Year of publication
1994
Pages
1535 - 1549
Database
ISI
SICI code
0732-8311(1994)13:6-7<1535:NAN.TS>2.0.ZU;2-L
Abstract
New synthetic methods for pyrimidine ring-expanded xanthosine, guanosi ne, and inosine analogues containing imidazo[4,5-e][1,4]diazepine nucl eus are described. Treatment of N-1-substituted inosine derivatives 5, 12, 19 with aqueous NaOH gave 5-amino-4-(N-substituted carbamoyl)imid azole derivatives, followed by appropriate manipulations to cyclize th ese to constitute imidazo[4,5-e][1,4]diazepine nucleosides 11, 17, 22.