Pm. Jung et al., HYBRIDIZATION OF ALTERNATING CATIONIC ANIONIC OLIGONUCLEOTIDES TO RNASEGMENTS/, Nucleosides & nucleotides, 13(6-7), 1994, pp. 1597-1605
It is shown that oligonucleotide analogues containing alternating phos
phodiester groups and cationic groups linked to phosphorus through an
amidate bond hybridize to complementary RNA segments. An improved synt
hetic procedure for the alternating compounds is also described.