INTRACAVERNOUS CALCITONIN-GENE-RELATED PEPTIDE PLUS PROSTAGLANDIN E(1) - POSSIBLE ALTERNATIVE TO PENILE IMPLANTS IN SELECTED PATIENTS

The implantation of a penile prosthesis is still the ultima ratio for patients with erectile dysfunction who fail other treatment options su ch as pharmacotherapy and penile venous surgery. Despite mostly favora ble results regarding restauration of erectile capacity, penile allogr afts are often not accepted for various reasons. Therefore, pharmacote sting with a mixture of calcitonin gene-related peptide and prostaglan din E(1) (CGRP/PGE(1)) was offered to different selected patients popu lations: 28 patients with erectile dysfunction and venous leakage who failed penile venous surgery, 28 patients with erectile dysfunction an d venous leakage (who refused penile venous surgery) and 12 patients w ithout venous leakage, but poor response to maximum doses of papaverin e/phentolamine, received 5 mu g CGRP plus 10 mu g PGE(1). Erections su fficient for intercourse were noted in 19/28 (67.9%), 20/28 (71.4%) an d 11/12 (91.7%) patients, respectively. Our data show that a combinati on of CGRP and PGE(1) may be an alternative to penile implants in sele cted patients.