REGIONAL OXYGEN-CONSUMPTION PERSISTS IN DYSKINETIC CANINE MYOCARDIUM

Authors
BUFFINGTON CW STRUM DP WATANABE S
Citation
Cw. Buffington et al., REGIONAL OXYGEN-CONSUMPTION PERSISTS IN DYSKINETIC CANINE MYOCARDIUM, Journal of cardiovascular pharmacology, 24(1), 1994, pp. 37-44
Citations number
32
Categorie Soggetti
Cardiac & Cardiovascular System","Respiratory System","Pharmacology & Pharmacy
Journal title
Journal of cardiovascular pharmacology → ACNP
ISSN journal
01602446
Volume
24
Issue
1
Year of publication
1994
Pages
37 - 44
Database
ISI
SICI code
0160-2446(1994)24:1<37:ROPIDC>2.0.ZU;2-1
Abstract
Regional myocardial O-2 consumption was measured in anesthetized dogs both in baseline conditions and during intracoronary infusion of lidoc aine, verapamil, sodium citrate, or 2,3-butanedione-monoxime (BDM). De spite regional hypokinesis and dyskinesis during drug infusion, region al O-2 consumption was reduced only 30-40% by lidocaine, verapamil, an d citrate and not at all by BDM. These results cast doubt on an import ant assumption of the ''hibernation'' theory: the protective matching of regional perfusion and contraction.