CUTANEOUS ULTRAVIOLET-RADIATION INHIBITS HERPES-SIMPLEX VIRUS-INDUCEDLYMPHOPROLIFERATION IN LATENTLY INFECTED SUBJECTS

Authors
MIURA S KULKA TM SMITH CC IMAFUKU S BURNETT JW AURELIAN L
Citation
S. Miura et al., CUTANEOUS ULTRAVIOLET-RADIATION INHIBITS HERPES-SIMPLEX VIRUS-INDUCEDLYMPHOPROLIFERATION IN LATENTLY INFECTED SUBJECTS, Clinical immunology and immunopathology, 72(1), 1994, pp. 62-69
Citations number
42
Categorie Soggetti
Pathology,Immunology
Journal title
Clinical immunology and immunopathology → ACNP
ISSN journal
00901229
Volume
72
Issue
1
Year of publication
1994
Pages
62 - 69
Database
ISI
SICI code
0090-1229(1994)72:1<62:CUIHV>2.0.ZU;2-F
Abstract
Exposure of herpes simplex virus (HSV) latently infected subjects to u ltraviolet irradiation (UVR) (1 minimum erythema dose, 90% body surfac e) caused a significant inhibition of HSV and phytohemagglutinin-induc ed lymphoproliferation. The inhibition was observed on Day 3 post-UVR and lasted at least 9 days. UVR-induced downregulation of HSV-specific lymphoproliferation was associated with increased levels of activated transforming growth factor beta. However, the relationship between UV R-induced immune downregulation and the development of recurrent HSV l esions was incomplete. (C) 1994 Academic Press, Inc.