A SHORT AND EFFICIENT SYNTHESIS OF ECHIGUANINE-A AND ECHIGUANINE-B - POTENT INHIBITORS OF PHOSPHATIDYLINOSITOL-4-KINASE

Authors
SHIH C HU Y
Citation
C. Shih et Y. Hu, A SHORT AND EFFICIENT SYNTHESIS OF ECHIGUANINE-A AND ECHIGUANINE-B - POTENT INHIBITORS OF PHOSPHATIDYLINOSITOL-4-KINASE, Tetrahedron letters, 35(27), 1994, pp. 4677-4680
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
27
Year of publication
1994
Pages
4677 - 4680
Database
ISI
SICI code
0040-4039(1994)35:27<4677:ASAESO>2.0.ZU;2-L
Abstract
An efficient synthesis which utilizes a palladium catalyzed carbonylat ion reaction between 2-pivaloyl-7-iodo-7-deazaguanine and 3-aminopropi onitrile as a key step was developed for the preparation of a new clas s of pyrrolopyrimidine based PI 4-Kinase inhibitors: Echiguanines A an d B.