The ultrasonographic appearance of clinically undifferentiated neck ma
sses for which a definitive diagnosis was eventually obtained in ninet
een dogs and one cat is presented in this report. Multiple lesions wer
e seen ultrasonographically in 4 dogs and no cervical abnormalities we
re seen in 2 dogs resulting in 22 lesions in 20 animals. Of 7 benign l
esions, there were 2 patients with reactive lymph nodes from a regiona
l inflammatory process, and 1 patient each with primary pyogranulomato
us lymphadenitis, arteriovenous malformation, foreign body granuloma,
cellulitis, and hematoma. Of 15 malignant lesions, 7 were thyroid carc
inomas, 3 were lymphomas with submandibular and cervical lymph node en
largement, 3 were lymph node enlargements associated with regional met
astasis of malignant tumors, one was a leiomyosarcoma and one was a ca
rotid body tumor. One dog with a diffuse soft tissue swelling of the v
entral cervical region had only slight asymmetry of the thyroid lobes
on ultrasound examination and no abnormalities of the neck at post mor
tem. A second dog examined with ultrasound 4 months after surgical rem
oval of a carotid body tumor had no evidence of tumor recurrence. Ultr
asonographic examination provided information regarding the character
of the lesions, the tissue or organ of origin, and invasion into other
anatomic structures. Ultrasound examination in conjunction with fine
needle or tissue biopsy provided a definitive diagnosis in those anima
ls in which biopsies were performed.