STUDY ON MODEL CLUSTERS OF METALLOTHIONEIN - STRUCTURE AND ITS KINETICS OF ZINC TRANSFER-REACTION TO APO-CARBONIC ANHYDRASE

Authors
HUANG ZX HU HY GU WQ WU G
Citation
Zx. Huang et al., STUDY ON MODEL CLUSTERS OF METALLOTHIONEIN - STRUCTURE AND ITS KINETICS OF ZINC TRANSFER-REACTION TO APO-CARBONIC ANHYDRASE, Journal of inorganic biochemistry, 54(2), 1994, pp. 147-155
Citations number
26
Categorie Soggetti
Biology,"Chemistry Inorganic & Nuclear
Journal title
Journal of inorganic biochemistry → ACNP
ISSN journal
01620134
Volume
54
Issue
2
Year of publication
1994
Pages
147 - 155
Database
ISI
SICI code
0162-0134(1994)54:2<147:SOMCOM>2.0.ZU;2-V
Abstract
In order to investigate the relationship between the structure and fun ctions of metallothioneins, [(CH3)(4)N](2)[Zn-4(SC6H5)(10)], as a mode l cluster of metallothionein has been synthesized. The structure of th e model cluster has been examined by a CAD-4 x-ray diffractometer and the kinetics of zinc transfer reaction to apocarbonic anhydrase has be en studied. Structural analysis and kinetic study show that compared w ith the model cluster the clusters in metallothionein are structurally more loose and they have a similar reactivity of zinc transfer.