BONE-MARROW TRANSPLANTATION IN IRAN

Seventy-three BMT procedures (42 allogeneic-BMT, 30 autologous-BMT, 1 syngeneic transplant) were undertaken at the Shariati Hospital in Tehr an between March 1991 and November 1993. Allogeneic-BMT was performed for thalassaemia major (n = 23), AML in complete remission (n = 3), se vere aplastic anaemia (n = 7), CML (n = 7), dyskeratosis congenita (n = 2) and Fanconi anaemia (n = 1). Conditioning regimens comprised busu lphan (BU) plus cyclophosphamide (CY) or CY only. Thirty-two (78%) of the 43 patients remain alive 1-34 months after BMT. Twelve patients di ed: the causes of death were haemorrhagic cystitis (n = I), CMV pneumo nitis (It = 1), GVHD (n = 3), infection (n = 3), rejection (n = 1), VO D (n = 2) and hepatitis (n = 1). Autologous-BMT was performed for pati ents with AML in CR (n = 16), ALL in CR (n = 9), lymphoma in relapse ( n = 3), Ewing sarcoma (n = 1) and multiple myeloma (n = 1). The median age was 18 years. Conditioning regimens were Ara C plus CY, etoposide plus CY and high-dose melphalan. Sixteen (54%) of the 30 patients sur vive, 14 in continuous complete remission. The causes of death were re lapse (AML (n = 7), ALL (n = 4), lymphoma (n = 1)), VOD (n = 1) and in fection (n = 1).