ALLOGENEIC BONE-MARROW TRANSPLANTATION FROM A RELATED DONOR UNDERGOING LONG-TERM IMMUNOSUPPRESSIVE AND CYTOTOXIC THERAPY

We report the case of a patient with acute myeloid leukemia in second remission who received an allogeneic bone marrow transplant from an im munosuppressed HLA-identieal sibling donor. The donor was receiving pr ednisone, azathioprine and cyclosporine for a cadaveric renal allograf t. Bone marrow growth in culture from the donor was normal. Engraftmen t was within normal limits. Moderate acute graft-versus-host disease ( GVHD) developed. We suggest that transplants from immunosuppressed don ors are feasible and that this does not preclude the development of GV HD.