A. Pastor et al., SYNTHESIS AND STRUCTURE OF NEW PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES WITH CALCIUM-CHANNEL ANTAGONIST ACTIVITY, Tetrahedron, 50(27), 1994, pp. 8085-8098
Several series of pyrido[2,3-d]pyrimidine derivatives were synthesized
by reaction of aryl methyleneacetoacetates with different aminopyrimi
dines. The solid-state structure of the methyl 5,8-hexahydropyrido[2,3
-d]pyrimidine-6-carboxylate shows that these compounds can adopt some
of the most important structural features of the 1,4-dihydropyridine c
alcium channel blockers. The scope and limitations of the synthetic pr
ocedure with different aminoheterocycles is presented together with th
e initial evaluation of their calcium antagonistic activity by compari
son with the usual reference compound nifedipine.