SYNTHESIS OF 2-ACYLAMINOBENZIMIDAZOLES FROM ACYL ISOTHIOCYANATES AND O-PHENYLENEDIAMINE

Authors
KUTSCHY P FICERI V DZURILLA M
Citation
P. Kutschy et al., SYNTHESIS OF 2-ACYLAMINOBENZIMIDAZOLES FROM ACYL ISOTHIOCYANATES AND O-PHENYLENEDIAMINE, Chemicke zvesti, 48(1), 1994, pp. 39-42
Citations number
19
Categorie Soggetti
Chemistry
Journal title
Chemicke zvesti → ACNP
ISSN journal
03666352
Volume
48
Issue
1
Year of publication
1994
Pages
39 - 42
Database
ISI
SICI code
0366-6352(1994)48:1<39:SO2FAI>2.0.ZU;2-3
Abstract
Acyl isothiocyanates react with o-phenylenediamine in anhydrous aceton itrile in the presence of dicyclohexylcarbodiimide as cyclodesulfurizi ng agent with the formation of acyl derivatives of 2-aminobenzimidazol e. Intermediates of the reaction are corresponding N-(2-aminophenyl)-N '-acylthioureas readily formed at laboratory temperature, which cycliz e to benzimidazole derivatives by the action of dicyclohexylcarbodiimi de in boiling acetonitrile.