C-FOS EXPRESSION AFTER SINGLE AND KINDLED AUDIOGENIC-SEIZURES IN WISTAR RATS

In naive Wistar rats susceptible to sound, a single audiogenic seizure induced the expression of c-fos in the subcortical auditory nuclei wh ereas the forebrain was almost completely devoid of any labelling. Aft er kindling of audiogenic seizures by 40 daily exposures to sound, the seizure induced a strong c-fos expression in the amygdala, the pirifo rm cortex, the hippocampus and the neocortex. These results confirm: ( i) that audiogenic seizures are brain-stem seizures related to dysfunc tion of auditory pathways, and (ii) that kindling of audiogenic seizur es recruits forebrain and limbic structures into the seizure network.