ENHANCED CYTOTOXICITY OF AMYLOID BETA-PEPTIDE BY A COMPLEMENT-DEPENDENT MECHANISM

Authors
SCHULTZ J SCHALLER J MCKINLEY M BRADT B COOPER N MAY P ROGERS J
Citation
J. Schultz et al., ENHANCED CYTOTOXICITY OF AMYLOID BETA-PEPTIDE BY A COMPLEMENT-DEPENDENT MECHANISM, Neuroscience letters, 175(1-2), 1994, pp. 99-102
Citations number
11
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
175
Issue
1-2
Year of publication
1994
Pages
99 - 102
Database
ISI
SICI code
0304-3940(1994)175:1-2<99:ECOABB>2.0.ZU;2-3
Abstract
Amyloid beta-peptide (A beta) has been shown to activate the classical complement pathway in vitro. Here, we demonstrate that this interacti on is fully capable of killing cells and damaging cellular processes i n mixed hippocampal cultures from embryonic day 18 rat fetuses. Lactic acid dehydrogenase (LDH) release and morphologic changes were used to evaluate toxicity.