DESIGN AND SYNTHESIS OF NOVEL MUSCARINIC AGONISTS CONTAINING THE 1,2,4-TRIAZINE RING AS AN ESTER BIOISOSTERE

Authors
ORLEK BS CASSIDY F CLARK MSG FAULKNER RE COLLINGS EJ HAWKINS J RILEY GJ
Citation
Bs. Orlek et al., DESIGN AND SYNTHESIS OF NOVEL MUSCARINIC AGONISTS CONTAINING THE 1,2,4-TRIAZINE RING AS AN ESTER BIOISOSTERE, Bioorganic & medicinal chemistry letters, 4(12), 1994, pp. 1411-1414
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
12
Year of publication
1994
Pages
1411 - 1414
Database
ISI
SICI code
0960-894X(1994)4:12<1411:DASONM>2.0.ZU;2-A
Abstract
Replacement of the ester group in methyl quinuclidine-3-carboxylate 1 with a 1,2,4-triazine ring afforded the high affinity muscarinic parti al agonist 6a. Analogues 7a, 7b and 7d which incorporate the 1-azabicy clo[2.2.1]heptane ring also display high affinity for muscarinic recep tors.