IDENTIFICATION OF A SULFATED TETRASACCHARIDE WITH HEPARIN-LIKE ANTIPROLIFERATIVE ACTIVITY

Authors
WESSEL HP TSCHOPP TB HOSANG M IBERG N
Citation
Hp. Wessel et al., IDENTIFICATION OF A SULFATED TETRASACCHARIDE WITH HEPARIN-LIKE ANTIPROLIFERATIVE ACTIVITY, Bioorganic & medicinal chemistry letters, 4(12), 1994, pp. 1419-1422
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
12
Year of publication
1994
Pages
1419 - 1422
Database
ISI
SICI code
0960-894X(1994)4:12<1419:IOASTW>2.0.ZU;2-#
Abstract
Investigation of the smooth muscle cell antiproliferative activities o f Trestatin A sulfate substructures showed that a sulfated pentasaccha ride is required to maintain a heparin-like effect. The modification o f one glycosidic bond led to a synthetically readily available tetrasa ccharide, namely sulfated beta-maltosyl trehalose 12, with similar ant iproliferative but devoid of anticoagulant activity.