A CONGENER STUDY OF ZILEUTON REVEALS INTERESTING EFFECTS ON GLUCURONIDATION RATES

Authors
GALEAZZI E GUZMAN A KLUGE A MORGANS D MUCHOWSKI J JAMILPANAH S SAAVEDRA P SALAZAR MA TALAMAS FX TEITELBAUM P YOUNG J YAMAMOTO D
Citation
E. Galeazzi et al., A CONGENER STUDY OF ZILEUTON REVEALS INTERESTING EFFECTS ON GLUCURONIDATION RATES, Bioorganic & medicinal chemistry letters, 4(12), 1994, pp. 1437-1442
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
12
Year of publication
1994
Pages
1437 - 1442
Database
ISI
SICI code
0960-894X(1994)4:12<1437:ACSOZR>2.0.ZU;2-5
Abstract
Heteroatom substitution within the zileuton nucleus led to a congener series which was evaluated for potency and rate of glucuronidation, a major route for elimination of zileuton. Subtle changes in structure w ere found to significantly effect glucuronidation rate.