STRUCTURAL BASIS FOR THE DIFFERENTIAL RXR AND RAR ACTIVITY OF STILBENE RETINOID ANALOGS

Authors
BEARD RL GIL DW MARLER DK HENRY E COLON DF GILLETT SJ AREFIEG T BREEN TS KRAUSS H DAVIES PJA CHANDRARATNA RAS
Citation
Rl. Beard et al., STRUCTURAL BASIS FOR THE DIFFERENTIAL RXR AND RAR ACTIVITY OF STILBENE RETINOID ANALOGS, Bioorganic & medicinal chemistry letters, 4(12), 1994, pp. 1447-1452
Citations number
44
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
12
Year of publication
1994
Pages
1447 - 1452
Database
ISI
SICI code
0960-894X(1994)4:12<1447:SBFTDR>2.0.ZU;2-7
Abstract
Retinoids elicit their biological actions by activating nuclear recept ors that regulate gene transcription. There are six known retinoid rec eptors which belong to the retinoic acid receptor (RAR) and retinoid X receptor (RXR) families. We report RXR-active stilbene retinoid analo gs and discuss the structural features that impart RAR and RXR activat ion properties to compounds of this class.