L-161,638 - A POTENT AT(2) SELECTIVE QUINAZOLINONE ANGIOTENSIN-II BINDING INHIBITOR

Authors
GLINKA TW DELASZLO SE TRAN J CHANG RS CHEN TB LOTTI VJ GREENLEE WJ
Citation
Tw. Glinka et al., L-161,638 - A POTENT AT(2) SELECTIVE QUINAZOLINONE ANGIOTENSIN-II BINDING INHIBITOR, Bioorganic & medicinal chemistry letters, 4(12), 1994, pp. 1479-1484
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
12
Year of publication
1994
Pages
1479 - 1484
Database
ISI
SICI code
0960-894X(1994)4:12<1479:L-APAS>2.0.ZU;2-J
Abstract
The relative AT(1) and AT(2) binding affinities of l-5-yl)biphenyl-4-y l)methyl]quinazolin-4-(3H)-ones can be manipulated by changing the sub stitution at positions C-2 and N-6 of the quinazolinone nucleus. L-161 ,638 was identified as a potent orally bioavailable and AT(2) selectiv e angiotensin II binding inhibitor.