SYNTHESIS OF RING-A-OPENED ISOPICROPODOPHYLLINS AS POTENTIAL DNA TOPOISOMERASE-II INHIBITORS

Authors
KAMAL A DANESHTALAB M ATCHISON K MICETICH RG
Citation
A. Kamal et al., SYNTHESIS OF RING-A-OPENED ISOPICROPODOPHYLLINS AS POTENTIAL DNA TOPOISOMERASE-II INHIBITORS, Bioorganic & medicinal chemistry letters, 4(12), 1994, pp. 1513-1518
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
12
Year of publication
1994
Pages
1513 - 1518
Database
ISI
SICI code
0960-894X(1994)4:12<1513:SORIAP>2.0.ZU;2-A
Abstract
Some representative ring-A-opened podophyllin lignans were synthesized employing the Michael Initiated Ring Closure methodology. These ligna ns exhibited considerable DNA topoisomerase II inhibition and were dev oid of topoisomerase I inhibition.