IMIDAZOLINONES AS NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS

Authors
QUAN ML DELUCCA I BOSWELL GA CHIU AT WONG PC WEXLER RR TIMMERMANS PBMWM
Citation
Ml. Quan et al., IMIDAZOLINONES AS NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 4(12), 1994, pp. 1527-1530
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
12
Year of publication
1994
Pages
1527 - 1530
Database
ISI
SICI code
0960-894X(1994)4:12<1527:IANARA>2.0.ZU;2-0
Abstract
A series of biphenyl imidazolinones were synthesized as nonpeptide ang iotensin II receptor antagonists. While those compounds with a tetrazo le functionality were found to be AT(1) selective, those with a sulfon amide moiety showed affinities for both the AT(1) and the AT(2) sites. Representative compounds were very active in lowering blood pressure in conscious renal hypertensive rats following intravenous administrat ion.