CHARACTERIZATION OF THE TAXOL STRUCTURE-ACTIVITY PROFILE FOR THE LOCUS OF THE A-RING SIDE-CHAIN

Authors
SWINDELL CS HEERDING JM KRAUSS NE HORWITZ SB RINGEL I
Citation
Cs. Swindell et al., CHARACTERIZATION OF THE TAXOL STRUCTURE-ACTIVITY PROFILE FOR THE LOCUS OF THE A-RING SIDE-CHAIN, Bioorganic & medicinal chemistry letters, 4(12), 1994, pp. 1531-1536
Citations number
42
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
12
Year of publication
1994
Pages
1531 - 1536
Database
ISI
SICI code
0960-894X(1994)4:12<1531:COTTSP>2.0.ZU;2-6
Abstract
Two series of taxol analogs with various N-acyl groups on 3'-phenyliso serine and isoserine A-ring side chains, respectively, were prepared, and their microtubule assembly activities and cytotoxicities toward J7 74.2 cells were evaluated. Biological activities were adversely affect ed by the structural modifications investigated, although the 3'-pheny lisoserine series was significantly more active than the isoserine ser ies.