2 NEW PHOSPHOLIPASE-D INHIBITORS, SCH-49211 AND SCH-49212, PRODUCED BY THE FUNGUS NATTRASSIA-MANGIFERAE

Authors
CHU M TRUUMEES I PATEL MG GULLO VP PAI JK DAS PR PUAR MS
Citation
M. Chu et al., 2 NEW PHOSPHOLIPASE-D INHIBITORS, SCH-49211 AND SCH-49212, PRODUCED BY THE FUNGUS NATTRASSIA-MANGIFERAE, Bioorganic & medicinal chemistry letters, 4(12), 1994, pp. 1539-1542
Citations number
3
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
12
Year of publication
1994
Pages
1539 - 1542
Database
ISI
SICI code
0960-894X(1994)4:12<1539:2NPISA>2.0.ZU;2-J
Abstract
Sch 49211 (2) and Sch 49212 (3) have been isolated from the fermentati on of the fungus Nattrassia mangiferae. The strucutres of 2 and 3 were determined by analysis of NMR spectroscopic data. Both 2 and 3 exhibi t inhibitory activity (IC50 = 11 and 12 mu M, respectively) in the pho spholipase D (PLD) assay.