CLINICAL-EVALUATION OF PLASMA-EXCHANGE AND HIGH-DOSE INTRAVENOUS IMMUNOGLOBULIN IN A PATIENT WITH ISAACS SYNDROME

The clinical effects of plasma exchange and high dose intravenous immu noglobulin (IVIg) were evaluated in a 41 year old woman with Isaacs' s yndrome. After double filtration plasma exchange, symptoms almost disa ppeared for two to three weeks and the recorded continuous muscle acti on potentials were considerably decreased. Symptoms recurred within a few months. On the other hand, IVIg worsened the symptoms of the disor der: during and after IVIg at a dose of 0.2 g/kg/day (total 50 g), wid espread myokymia, pseudomyotonia, and muscle cramps gradually increase d. Symptoms improved after another course of plasma exchange.