GASTRIN-RELEASING PEPTIDE AND CCK AFTER INTRADUODENAL INHIBITION OF PROTEASES IN DOGS

The intraduodenal application of a potent protease inhibitor (camostat e, 600 mg) causes a significant increase in basal pancreatic secretion in the manner of a negative-feedback mechanism. The integrated protei n secretion during the entire study period was 9.9 +/- 1.8 g in 120 mi n. The iv application of anti-GRP immunoglobulin caused a significant reduction to 5.0 +/- g in 120 min. No significant changes in the plasm a concentrations of GRP and CCK were detectable. The increased secreti on occurring after the administration of the protease inhibitor could be mediated by neural GRP-dependent mechanisms. These may also be rele vant for CCK-dependent factors, which are only briefly mentioned.