C-MYC BINDS TO 5' FLANKING SEQUENCE MOTIFS OF THE DIHYDROFOLATE-REDUCTASE GENE IN CELLULAR-EXTRACTS - ROLE IN PROLIFERATION

Authors
MAI S JALAVA A
Citation
S. Mai et A. Jalava, C-MYC BINDS TO 5' FLANKING SEQUENCE MOTIFS OF THE DIHYDROFOLATE-REDUCTASE GENE IN CELLULAR-EXTRACTS - ROLE IN PROLIFERATION, Nucleic acids research, 22(12), 1994, pp. 2264-2273
Citations number
57
Categorie Soggetti
Biology
Journal title
Nucleic acids research → ACNP
ISSN journal
03051048
Volume
22
Issue
12
Year of publication
1994
Pages
2264 - 2273
Database
ISI
SICI code
0305-1048(1994)22:12<2264:CBT5FS>2.0.ZU;2-U
Abstract
The dihydrofolate reductase is a key enzyme of the folate metabolism w hich supplies the cell with dTTPs for DNA synthesis. Using cellular ex tracts, we demonstrate the formation of c-Myc/Max heterodimers at the dihydrofolate reductase (DHFR) 5' flanking CANNTG (E-box) motifs. The presence of these complexes correlates with c-Myc levels and active ce llular proliferation.