SYNTHESIS OF TAXOL FROM BACCATIN IN VIA AN OXAZOLINE INTERMEDIATE

Authors
KINGSTON DGI CHAUDHARY AG GUNATILAKA AAL MIDDLETON ML
Citation
Dgi. Kingston et al., SYNTHESIS OF TAXOL FROM BACCATIN IN VIA AN OXAZOLINE INTERMEDIATE, Tetrahedron letters, 35(26), 1994, pp. 4483-4484
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
26
Year of publication
1994
Pages
4483 - 4484
Database
ISI
SICI code
0040-4039(1994)35:26<4483:SOTFBI>2.0.ZU;2-Y
Abstract
Taxol (1) can be prepared in good yield by coupling the oxazoline carb oxylic acid 5 with 7-(triethylsilyl)baccatin III, followed by hydrolys is. The oxazolines 7 and 8 can also be prepared directly from taxol.