Tp. Curran et al., CIS-3,5-DIMETHYL-3,5-PIPERIDINEDICARBOXYLIC ACID, AN AMINO DIACID VARIANT OF KEMPS TRIACID, Tetrahedron letters, 35(26), 1994, pp. 4515-4518
Cis-3,5-dimethyl-3,5-piperidinedicarboxylic Acid (3) and several of it
s derivatives have been synthesized starting from 3,5-pyridinedicarbox
ylic acid. The H-1 NMR spectra indicate that these compounds assume a
single conformation having the two carbonyl substituents in axial posi
tions.