THE SYNTHESIS OF BRANCHED STEROIDAL PRODRUGS OF NITROGEN-MUSTARD FOR ANTITUMOR TARGETING VIA RECONSTITUTED LDL

Authors
DUBOWCHIK GM FIRESTONE RA
Citation
Gm. Dubowchik et Ra. Firestone, THE SYNTHESIS OF BRANCHED STEROIDAL PRODRUGS OF NITROGEN-MUSTARD FOR ANTITUMOR TARGETING VIA RECONSTITUTED LDL, Tetrahedron letters, 35(26), 1994, pp. 4523-4526
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
26
Year of publication
1994
Pages
4523 - 4526
Database
ISI
SICI code
0040-4039(1994)35:26<4523:TSOBSP>2.0.ZU;2-H
Abstract
Bis and tris nitrogen mustard oleoyl-steroid carbamates were synthesiz ed from commercially available cholenic acids for antitumor drug targe ting via the LDL pathway. The tris-mustards were prepared through trie ster intermediates made from selective alkylation of the dianion of t- butyl 3-(diethyl malonyl)propionate 10 with steroid iodides 8.