HIGHLY EFFICIENT ENZYMATIC ASYMMETRIC REDUCTION BY USE OF REGENERATION NADPH IN BAKERS-YEAST CELL-FREE-EXTRACT

Authors
ISHIHARA K SAKAI T TSUBOI S UTAKA M
Citation
K. Ishihara et al., HIGHLY EFFICIENT ENZYMATIC ASYMMETRIC REDUCTION BY USE OF REGENERATION NADPH IN BAKERS-YEAST CELL-FREE-EXTRACT, Tetrahedron letters, 35(26), 1994, pp. 4569-4570
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
26
Year of publication
1994
Pages
4569 - 4570
Database
ISI
SICI code
0040-4039(1994)35:26<4569:HEEARB>2.0.ZU;2-Z
Abstract
Bakers' yeast cell-free extract was found to reduce 1-acetoxy-2-alkano nes to (S)-1-acetoxy-Z-alkanols in 59 - 88% yield and 95 - >99% ee by use of a catalytic amount of NADPH with glucose as a hydride source an d without addition of any enzyme for the cofactor regeneration.