10-MEMBERED NEOCARZINOSTATIN CHROMOPHORE ANALOGS LEADING TO SIGMA,SIGMA-BIRADICAL VIA A CUMULENE INTERMEDIATE

Authors
KAWATA S OISHI T HIRAMA M
Citation
S. Kawata et al., 10-MEMBERED NEOCARZINOSTATIN CHROMOPHORE ANALOGS LEADING TO SIGMA,SIGMA-BIRADICAL VIA A CUMULENE INTERMEDIATE, Tetrahedron letters, 35(26), 1994, pp. 4595-4598
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
26
Year of publication
1994
Pages
4595 - 4598
Database
ISI
SICI code
0040-4039(1994)35:26<4595:1NCALT>2.0.ZU;2-A
Abstract
New neocarzinostatin chromophore analogs of 10-membered ring are synth esized. Generation of sigma,sigma-biradical via a cumulene intermediat e has been demonstrated. The DNA-cleaving activity of the hybrid 5 is found to be 50-fold more potent than 1.