EFFICACY AND TOLERABILITY OF ETOFIBRATE AND GEMFIBROZIL IN COMBINED HYPERLIPEMIA

In a controlled clinical trial with a placebo prephase, the comparison of the two lipid-lowering drugs etofibrate and gemfibrozil showed no clinically relevant differences of lipoprotein profile modification in 50 patients with combined hyperlipidaemia. Under both treatments, the re was a marked and significant reduction of triglycerides associated with a significant decrease of total cholesterol. in both treatment gr oups, the percent increase of high density lipoprotein HDL cholesterol was significantly correlated to the pretreatment levels of HDL choles terol. Tolerance was better under etofibrate with no reported side eff ects compared to gemfibrozil with two reported cases of gastrointestin al side effects.