SYNTHESIS OF ISOTOPICALLY-LABELED NITROXYL RADICALS FOR USE AS SPIN PROBES

The synthesis of [N-15]-1,1,1,1,3, 3-tetrakis(trideuteriomethyl)isoind olin- and of some 5-alkyl derivatives have been achieved by standard s ynthetic routes.(1) The presence of deuterium improves the sharpness o f the signals, and this, together with the incorporation of nitrogen-1 5, enhances the application of such compounds as spin probes; alkyl su bstituents at C-5 improve the lipophilicity.