SYNTHESIS OF A I-125 LABELED AZIDO-SUBSTITUTED GLIBENCLAMIDE ANALOG FOR PHOTOAFFINITY-LABELING OF THE SULFONYLUREA RECEPTOR

Authors
CHUDZIAK F SCHWANSTECHER M LAATSCH H PANTEN U
Citation
F. Chudziak et al., SYNTHESIS OF A I-125 LABELED AZIDO-SUBSTITUTED GLIBENCLAMIDE ANALOG FOR PHOTOAFFINITY-LABELING OF THE SULFONYLUREA RECEPTOR, Journal of labelled compounds & radiopharmaceuticals, 34(7), 1994, pp. 675-680
Citations number
16
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
34
Issue
7
Year of publication
1994
Pages
675 - 680
Database
ISI
SICI code
0362-4803(1994)34:7<675:SOAILA>2.0.ZU;2-1
Abstract
N-[4-(2-(4-Azido-2-hydroxy-5-[I-125]iodobenzamido )ethyl)benzenesulfon yl]-N'cyclohexylurea has been prepared as a novel photoaffinity ligand for the sulfonylurea receptor. This involved synthesis of a 4-azidosa licy]oyl analogue of glibenclamide and treatment of the analogue with (NaI)-I-125 and chloramine-T. Purification by HPLC gave the radiolabel led sulonylurea in 56% radiochemical yield and high specific activity (2130 Ci/mmol).