EFFECTS OF COCAINE ON THE DEVELOPMENT OF MOLONEY SARCOMA VIRUS-INDUCED TUMORS IN MICE

Authors
FREIREGARABAL M NUNEZ MJ LOSADA C PEREIRO D CASTROBOLANO C SABURIDO XL NUNEZ R MATOS L VARELAPATINO MP REYMENDEZ M
Citation
M. Freiregarabal et al., EFFECTS OF COCAINE ON THE DEVELOPMENT OF MOLONEY SARCOMA VIRUS-INDUCED TUMORS IN MICE, Research communications in substance abuse, 15(1-2), 1994, pp. 105-112
Citations number
23
Categorie Soggetti
Substance Abuse
Journal title
Research communications in substance abuse → ACNP
ISSN journal
01930818
Volume
15
Issue
1-2
Year of publication
1994
Pages
105 - 112
Database
ISI
SICI code
0193-0818(1994)15:1-2<105:EOCOTD>2.0.ZU;2-K
Abstract
Experiments were conducted to evaluate the effects of cocaine (0.5 mg/ kg) on the development of autochthonous tumors induced by the Moloney sarcoma virus (MSV) in adult BALB/c female mice. Enhancement of MSV-in duced tumor incidence and tumor growth together with a delay in the us ual prompt regression of the tumors were observed when mice were daily injected with cocaine for 3 days after MSV-inoculation. However, no s ignificant effects of cocaine on tumor development were found when it was administered during the 3 days before tumor was inoculated.