BEHAVIORAL-EFFECTS OF AN ANTIANDROGEN IN ADULT MALE RHESUS MACAQUES (MACACA-MULATTA)

This study was designed to determine how to suppress behavioral effect s of androgens with a pure non-steroidal antiandrogen, Hydroxyflutamid e (OHF). The major dependent variable was yawning behavior of castrate d adult male rhesus macaques. Injections of testosterone propionate (T P) increased yawning frequency and cessation of TP injections produced a decrease in yawning frequency. A similar decrease was observed with simultaneous injections of TP and OHF. It has been found that the dos e of OHF injected subcutaneously should be 80 times that of TP to bloc k the effects of either physiological or supraphysiological doses of T P. (C) 1994 Academic Press, Inc.